Uromax®

Improve urinary tract infection & inflammation
 

Lower urinary tract infections (UTIs) are very common and have been estimated to occur in at least 60% of women at some stage during their lives. Because of their high prevalence, UTIs are a public health concern for high cost of diagnosis and treatment. UTIs are approximately 50-fold more common in adult females than males because women have shorter urethras that allow bacteria to ascend into the bladder. The first step in an infection is the colonization of the periurethral tissues, followed by the passage of bacteria through the urethra. The second step is the adherence of bacteria to the urethra and bladder walls and proliferation. UTIs are caused mainly by Gram-negative bacteria. Indeed, Escherichia coli (E. coli) account for most cases. Treatment usually involves antibiotics, and recurrence is a major concern.

The risk factors that predispose women to recurrent UTIs include genetic, sexual intercourse, abnormalities in the structure of urinary tract, the use of contraception, antimicrobial resistance, menopause, genetics and bacterial virulence. Women with diabetes may be at higher risk, as well, because their compromised immune systems make them less able to fight off infections like UTIs. Other conditions that increase risk include pregnancymultiple sclerosis and kidney stones. 

Focusing on UTI prevention became a major goal because of their recurrent nature, increasing antimicrobial resistance and medical costs. The current management of recurrent UTIs involves either repeated courses of antibiotics or low-dose, long-term antibiotic prophylaxis. Although effective, these treatments have side effects, such as fungal super-infection (oral or vaginal thrush) and gastrointestinal infections, notably Clostridium difficile. Some options to avoid this risk are available, including the use of cranberry products.

Indications:

-Treatment of urinary tract infections

– Prevention of recurrent infections

– Boosts immune system

Ingredients:

 Vaccinium macrocarpon

 Common name: Cranberry

 

Cranberries are part of the Ericaceae family. Recent observational and clinical studies have raised interest in the potential health effects of cranberry consumption, an association that appears to be due to the phytochemical content of this fruit. The profile of cranberry bioactives is distinct from that of other berry fruit, being rich in A-type proanthocyanidins (PACs) in contrast to the B-type PACs present in most other fruit. It also composed of fructose and high level of vitamin C. The anthocyanidins and proanthocyanidins (PAC) are tannins (stable polyphenols) found only in vaccinium berries and function as a natural plant defense system against microbes.Cranberry juice has been the traditional choice of most women seeking to prevent UTIs.Basic research has suggested a number of potential mechanisms of action of cranberry bioactives, although further molecular studies are necessary.

Mechanism of action

One important property of E.coli is its adherence to the host tissue. Proanthocyanidin content of cranberry prevents E. coli bacteria from sticking to the walls of the bladder, where they can cause infection. Without adhesion, the bacteria cannot infect the mucosal surface.

One study measured the levels of anthocyanins and PAC oligomers in urine after the consumption of dried cranberry juice. Experimental studies concerning human anthocyanins absorption after cranberry juice consumption demonstrated that 1 to 5% of the anthocyanins are excreted in the urine. Peak urinary anthocyanidin concentration is observed 3-6 hours after intake, and urinary excretion is nearly complete within the first 12 hours. They could bind to uropathogenic rectal E. coli isolates, thereby rendering them anti-adherent prior to their possible introduction into the urinary tract. Indeed, they could alter the bacterial selection pressure in the colon to favor nonadherent strain.The biosafety of cranberries has been tested, and no biochemical or hematological alterations were identified.

Vitamin C

Vitamin C, also known as ascorbic acid, is a water-soluble vitamin. Inside the body, vitamin C functions as an essential cofactor in numerous enzymatic reactions, e.g., in the biosynthesis of collagen, carnitine, and catecholamines and as a potent antioxidant

Vitamin C also affects several components of the human immune system. It has been shown to stimulate both the production and function  of leukocytes especially neutrophilslymphocytes, and phagocytes. Vitamin C boosts immune function.

It is often recommended as a supplement that can prevent UTI by acidification of the urine. This inhibits the growth of bacteria in the urinary tract. In vitro data now suggest that vitamin C can have a bacteriostatic effect in the urine. This effect was shown to be mediated by the reduction of urinary nitrites to reactive nitrogen oxides rather than by lowering urinary pH. Intake of ascorbic acid during pregnancy plays an effective roll in urinary infection prophylaxis.

 

Supplement Facts
Amount per tablet RDA%
Cranberry 600 mg *
Vitamin C 150 mg 167

Presentation:

30 tablets

Administration:

Take one tablet daily with meal.

 

Contraindications:

No contraindications have been reported to date.

This product includes extract of Cranberry which in patients with diabetes it is better to use cautiously and should consult a physician before using.

Pregnancy and Lactation:

This product is safe to use by pregnant or lactating women.

Pregnant or lactating women should consult a physician before using this product.

Interaction:

No interaction with other medicinal products has been reported to date.             
This product includes extract of Cranberry:

People who take antidepressants, NSAIDs, anti plaque and anti hypertensive medicines should consult a physician before using.

Adverse effect:

No adverse effect has been reported to date.

This product includes extract of Cranberry which may cause G.I upset, diarrhea and uric acid kidney stone formation.

Precautions:

Always read the label and use only as directed.           
 Keep out of reach of children.

Storage:

Keep in a cool (below 25°C) and dry place, away from direct sunlight